Schrödinger, Inc.

120 West 45th Street, 17th Floor

New York, New York 10036

August 10, 2020


Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549


  Re:   Schrödinger, Inc.
         Registration Statement on Form S-1
         Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Schrödinger, Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Registration Statement on Form S-1 filed on August 10, 2020 (the “Registration Statement”), so that it may become effective at 4:30 p.m. Eastern time on August 12, 2020, or as soon thereafter as practicable, or at such later time as the Registrant or its counsel may orally request via telephone call to the staff of the Securities and Exchange Commission.

Once the Registration Statement has been declared effective, please orally confirm that event with Cynthia T. Mazareas of Wilmer Cutler Pickering Hale and Dorr LLP at (617) 526-6393.

[Remainder of Page Intentionally Left Blank]

Very truly yours,



By:   /s/ Ramy Farid
  Name: Ramy Farid
  Title: President and Chief Executive Officer

Signature Page to Acceleration Request