1540 Broadway24th FloorNew YorkNYFALSE000149097800014909782022-11-032022-11-03

Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): November 3, 2022
Schrodinger, Inc.
(Exact name of Registrant as Specified in Its Charter)
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
(Commission File Number)
1540 Broadway, 24th Floor
New York, NY
(Address of principal executive offices)(Zip Code)
Registrant’s telephone number, including area code: (212) 295-5800
Not Applicable
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
oWritten communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
oSoliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
oPre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
oPre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading
Name of each exchange on which registered
Common stock, par value $0.01 per shareSDGRThe Nasdaq Stock Market LLC
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company o
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o

Item 2.02    Results of Operations and Financial Condition.
On November 3, 2022, Schrödinger, Inc. (the “Company”) issued a press release announcing its financial results for the third quarter ended September 30, 2022. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.
The information in this Form 8-K, including Exhibit 99.1 attached hereto, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing made by the Company under the Securities Act of 1933, as amended, or the Exchange Act, regardless of any general incorporation language in such filings, unless expressly incorporated by specific reference in such filing.
Item 9.01    Financial Statements and Exhibits.
104Cover Page Interactive Data File (embedded within the Inline XBRL document)

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
Schrödinger, Inc.
Date: November 3, 2022
By:/s/ Geoffrey Porges
 Geoffrey Porges, MBBS
Executive Vice President and Chief Financial Officer

Exhibit 99.1
Schrödinger Reports Third Quarter 2022 Financial Results
Total Revenue Growth of 24 Percent Over Third Quarter of 2021, Driven by Continued Progress Across Drug Discovery Portfolio

Full-Year 2022 Revenue Guidance Range Narrowed with Mix Shifting Toward Drug Discovery

Phase 1 Clinical Trial of MALT1 Inhibitor, SGR-1505, Open for Patient Enrollment

New Preclinical Data for CDC7 Inhibitor, SDGR-2921, to Be Presented at American Society of Hematology 2022 Annual Meeting

New York, November 3, 2022 – Schrödinger, Inc. (Nasdaq: SDGR), whose physics-based computational platform is transforming the way therapeutics and materials are discovered, today announced financial results for the third quarter of 2022.

“We delivered a strong quarter, with third quarter software revenue in line with our expectations and strong drug discovery revenue, reflecting progress across our portfolio of collaborative and proprietary programs,” stated Ramy Farid, Ph.D., chief executive officer at Schrödinger. “As we progress through the remainder of the year, we are focused on continuing to drive software adoption and advancing our pipeline. Today we announced that we’ve initiated our Phase 1 study for our MALT1 program and we are looking forward to presenting new preclinical data from our CDC7 program at the upcoming ASH meeting. We are very positive about the long-term potential of our underlying business – this quarter’s results highlight the benefits of our balanced model encompassing software licensing, collaborations and proprietary programs.”

Third Quarter 2022 Financial Highlights
Three Months Ended
September 30,
20222021% Change
(in millions)
Total revenue$37.0$29.924%
Software revenue$24.7$24.32%
Drug discovery revenue$12.3$5.6121%
Gross profit$17.2$11.155%
Software gross margin72.2 %72.8 %
Operating expenses$63.4$45.838%
Other income (expense)$6.5$(0.3)
Net loss$(39.9)$(35.0)

At September 30, 2022, Schrödinger had cash, cash equivalents, restricted cash and marketable securities of approximately $479 million, compared to approximately $513 million at June 30, 2022.

Recent Company Highlights
In October, Schrödinger hosted Platform Day during which the company provided a detailed review of its technology platform and demonstrated the impact of this platform across a growing portfolio that includes 9 collaborative programs in the clinic, 12 active collaborative projects and 18 proprietary programs. During the event, Schrödinger highlighted areas for future innovation and discussed the opportunities for value creation. The company also described six drug discovery case studies, including collaborative programs with Nimbus Therapeutics and Morphic Therapeutic as well as case studies from Schrödinger’s proprietary MALT1, CDC7 and Wee1 programs. Additionally, the company reviewed near- and longer-term opportunities for continued innovation of its physics-based computational platform, including increasing the number and type of discovery targets the platform can advance through hit identification, improving the effectiveness and efficiency with which the platform can advance targets through lead optimization, and expanding the applicability of the platform to new high-value areas.

In October, Schrödinger announced that it entered into a collaboration with Eli Lilly and Company. Under the terms of the agreement, Schrödinger is responsible for the discovery and optimization of small molecule compounds addressing an undisclosed target. Lilly is responsible for preclinical development, clinical development and commercialization. Schrödinger received an upfront payment and is eligible to receive up to $425 million in discovery, development and commercial milestone payments. Schrödinger is also eligible to receive low single- to low double-digit royalties on net sales of any products emerging from the collaboration in all markets.

Schrödinger today announced that its Phase 1 clinical trial of its MALT1 inhibitor, SGR-1505, is open to patient enrollment. This dose-escalation study is designed to evaluate the safety, pharmacokinetics, pharmacodynamics, and early signals of clinical activity of SGR-1505 as a monotherapy in patients with relapsed or refractory B-cell malignancies. Once the recommended dose is determined, an expansion cohort is planned to evaluate SGR-1505 in combination with other anti-cancer agents, such as BTK and BCL-2 inhibitors, in patients with specific B-cell malignancies.

Earlier today, Schrödinger announced that new preclinical data for SGR-2921, a CDC7 inhibitor, will be presented during a poster session at the American Society of Hematology (ASH) 64th Annual Meeting in December 2022. The data demonstrate the strong anti-tumor activity of SGR-2921 in preclinical models of acute myeloid leukemia (AML) both alone and in combination with standard of care therapies for the treatment of AML. SGR-2921 is advancing through IND-enabling studies to support a planned IND submission in the first half of 2023.

Schrödinger has identified multiple novel Wee1 inhibitors, and preclinical studies are ongoing. Schrödinger’s goal is to select a differentiated Wee1 inhibitor that demonstrates strong anti-tumor activity with limited off-target effects. The company now expects to select a Wee1 development candidate in the first half of 2023 and submit an IND in the first half of 2024. Wee1 is emerging as a potentially important therapeutic target for a range of solid tumors, including ovarian and uterine cancer.

In October, Schrödinger’s collaborator Morphic Therapeutic presented Phase 1 data from MORF-057 at the United European Gastroenterology Week 2022. These data reinforce previously reported safety and pharmacodynamic data from the MORF-057-101 study. MORF-057 is being developed as an oral α4β7 inhibitor candidate for the treatment of inflammatory bowel disease, with an initial focus in ulcerative colitis.

In August, Schrödinger’s collaborator Nimbus Therapeutics presented data at the American Chemical Society Fall 2022 meeting describing how structural biology and computational chemistry insights were leveraged to produce NDI-034858, its novel TYK2 inhibitor. Phase 2

clinical studies are ongoing to evaluate NDI-034858 in moderate-to-severe plaque psoriasis and psoriatic arthritis.

Schrödinger was recently ranked Number 21 on Newsweek’s List of “America's 100 Most Loved Workplaces.”

2022 Financial Outlook
As of November 3, 2022, Schrödinger outlined the following expectations for the fiscal year ending December 31, 2022:
Total revenue is now expected to range from $167 million to $175 million, compared to the prior expectation of $161 million to $181 million. The updated range represents growth of 21 percent to 27 percent over 2021.
Total software revenue is now expected to range from $122 million to $127 million, compared to the prior expectation of $126 million to $136 million. The updated range represents eight percent to 12 percent growth over 2021. The full year 2022 software revenue expectation implies fourth quarter 2022 software revenue to range from $34 million to $39 million.
Total drug discovery revenue is now expected to range from $45 million to $48 million, compared to the prior expectation of $35 million to $45 million. This higher range represents 82 percent to 94 percent growth over 2021.
Operating expense growth is now expected to be approximately 40 percent for 2022 compared to the prior expectation of slightly lower than 42 percent.
Software gross margin percentage is still expected to be in the mid-70s.

“Despite the challenging macroeconomic and industry environment, our tightened total revenue guidance for 2022 remains within our original range,” stated Geoff Porges, MBBS, chief financial officer at Schrödinger. “We consider our balanced business model to be one of our greatest strengths, and this quarter’s results reflect the growing contribution of our drug discovery portfolio to our operating results and overall value.”

Webcast and Conference Call Information
Schrödinger will host a conference call to discuss its third quarter 2022 financial results on Thursday, November 3, 2022, at 4:30 p.m. ET. The live webcast can be accessed under “News & Events” in the investors section of Schrödinger’s website, To participate in the live call, please register for the call here. It is recommended that participants register at least 15 minutes in advance of the call. Once registered, participants will receive the dial-in information. The archived webcast will be available on Schrödinger’s website for approximately 90 days following the event.

About Schrödinger
Schrödinger is transforming the way therapeutics and materials are discovered. Schrödinger has pioneered a physics-based computational platform that enables discovery of high-quality, novel molecules for drug development and materials applications more rapidly and at lower cost compared to traditional methods. The software platform is licensed by biopharmaceutical and industrial companies, academic institutions, and government laboratories around the world. Schrödinger’s multidisciplinary drug discovery team also leverages the software platform to advance a portfolio of collaborative and proprietary programs to address unmet medical needs.
Founded in 1990, Schrödinger has approximately 800 employees and is engaged with customers and collaborators in more than 70 countries. To learn more, visit, follow us on LinkedIn and Instagram, or visit our blog,

Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including, but not limited to those statements regarding Schrödinger’s expectations about the speed and capacity of its computational platform, its financial outlook for the

fiscal year ending December 31, 2022 and fourth quarter ending December 31, 2022, its plans to continue to invest in research and its strategic plans to accelerate the growth of its software licensing business and advance its collaborative and proprietary drug discovery programs, the long-term potential of its business, its ability to improve and advance the science underlying its platform, the initiation, timing, progress, and results of its proprietary drug discovery programs and product candidates and the drug discovery programs and product candidates of its collaborators, the clinical potential and favorable properties of its CDC7, MALT1, and Wee1 inhibitors, including SGR-1505 and SGR-2921, the clinical potential and favorable properties of its collaborators’ product candidates, as well as expectations related to the use of its cash, cash equivalents and marketable securities. Statements including words such as “aim,” “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and statements in the future tense are forward-looking statements. These forward-looking statements reflect Schrödinger’s current views about its plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the company and on assumptions the company has made. Actual results may differ materially from those described in these forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and important factors that are beyond Schrödinger’s control, including the demand for its software platform, its ability to further develop its computational platform, its reliance upon third-party providers of cloud-based infrastructure to host its software solutions, factors adversely affecting the life sciences industry, fluctuations in the value of the U.S. dollar and foreign currencies, its reliance upon its third-party drug discovery collaborators, the uncertainties inherent in drug development and commercialization, such as the conduct of research activities and the timing of and its ability to initiate and complete preclinical studies and clinical trials, whether results from preclinical studies will be predictive of the results of later preclinical studies and clinical trials, uncertainties associated with the regulatory review of IND submissions, clinical trials and applications for marketing approvals, the ability to retain and hire key personnel and the direct and indirect impacts of the ongoing COVID-19 pandemic on its business and other risks detailed under the caption “Risk Factors” and elsewhere in the company’s Securities and Exchange Commission filings and reports, including its Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2022, filed with the Securities and Exchange Commission on November 3, 2022, as well as future filings and reports by the company. Any forward-looking statements contained in this press release speak only as of the date hereof. Except as required by law, Schrödinger undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events, changes in expectations or otherwise.

Jaren Irene Madden (Investors)
Schrödinger, Inc.

Tracy Lessor (Media)
Schrödinger, Inc.

Condensed Consolidated Statements of Operations (Unaudited)
(in thousands, except for share and per share amounts)
Three Months Ended September 30,Nine Months Ended September 30,
Software products and services$24,667 $24,280 $87,759 $74,672 
Drug discovery12,313 5,570 36,353 17,089 
Total revenues36,980 29,850 124,112 91,761 
Cost of revenues:
Software products and services6,866 6,611 21,478 18,158 
Drug discovery12,913 12,124 40,316 34,344 
Total cost of revenues19,779 18,735 61,794 52,502 
Gross profit17,201 11,115 62,318 39,259 
Operating expenses:
Research and development32,885 23,219 91,830 65,759 
Sales and marketing7,161 5,556 21,260 16,175 
General and administrative23,318 17,014 67,507 46,253 
Total operating expenses63,364 45,789 180,597 128,187 
Loss from operations(46,163)(34,674)(118,279)(88,928)
Other (expense) income:
(Loss) gain on equity investments(3)— 11,825 (1,781)
Change in fair value5,273 (627)(16,591)19,279 
Other income1,231 286 1,263 1,063 
Total other income (expense)6,501 (341)(3,503)18,561 
Loss before income taxes(39,662)(35,015)(121,782)(70,367)
Income tax expense (benefit)194 (4)199 137 
Net loss(39,856)(35,011)(121,981)(70,504)
Net loss attributable to noncontrolling interest(3)(4)(2)(824)
Net loss attributable to Schrödinger common and limited common stockholders$(39,853)$(35,007)$(121,979)$(69,680)
Net loss per share attributable to Schrödinger common and limited common stockholders, basic and diluted:$(0.56)$(0.49)$(1.71)$(0.99)
Weighted average shares used to compute net loss per share attributable to Schrödinger common and limited common stockholders, basic and diluted:71,207,99270,784,18471,140,68270,481,901

Condensed Consolidated Balance Sheets (Unaudited)
(in thousands, except for share and per share amounts)
AssetsSeptember 30, 2022December 31, 2021
Current assets:
Cash and cash equivalents$102,817 $120,267 
Restricted cash5,803 3,000 
Marketable securities370,739 456,212 
Accounts receivable, net of allowance for doubtful accounts of $124 and $108
23,583 31,744 
Unbilled and other receivables, net for allowance for unbilled receivables of $40 and $30
12,155 8,807 
Prepaid expenses9,104 5,030 
Total current assets524,201 625,060 
Property and equipment, net13,755 10,025 
Equity investments27,177 43,167 
Goodwill4,791 — 
Intangible assets, net720 — 
Right of use assets88,462 75,384 
Other assets2,879 2,851 
Total assets$661,985 $756,487 
Liabilities and Stockholders' Equity:
Current liabilities:
Accounts payable$10,918 $8,079 
Accrued payroll, taxes, and benefits18,904 18,405 
Deferred revenue43,920 55,368 
Lease liabilities8,683 2,042 
Other accrued liabilities6,396 7,317 
Total current liabilities88,821 91,211 
Deferred revenue, long-term21,977 30,064 
Lease liabilities, long-term87,165 77,827 
Other liabilities, long-term900 300 
Total liabilities198,863 199,402 
Commitments and contingencies (Note 6)
Stockholders' equity:
Preferred stock, $0.01 par value. Authorized 10,000,000 shares; zero shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively
— — 
Common stock, $$0.01 par value. Authorized 500,000,000 shares; 62,067,768 and 61,834,515 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively
620 618 
Limited common stock, $0.01 par value. Authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively
92 92 
Additional paid-in capital818,015 786,964 
Accumulated deficit(351,931)(229,952)
Accumulated other comprehensive loss(3,686)(651)
Total stockholders' equity of Schrödinger stockholders463,110 557,071 
Noncontrolling interest12 14 
Total stockholders' equity463,122 557,085 
Total liabilities and stockholders' equity$661,985 $756,487 

Condensed Consolidated Statements of Cash Flows (Unaudited)
(in thousands)
Nine Months Ended September 30,
Cash flows from operating activities:
Net loss$(121,981)$(70,504)
Adjustments to reconcile net loss to net cash used in operating activities:
(Gain) loss on equity investments(11,825)1,781 
Noncash revenue from equity investments— (59)
Fair value adjustments16,591 (19,279)
Depreciation and amortization3,202 2,195 
Stock-based compensation29,425 19,034 
Noncash research and development expenses— 811 
Noncash investment amortization2,102 4,736 
Loss on disposal of property and equipment14 140 
Decrease (increase) in assets, net of acquisition:
Accounts receivable, net8,673 20,071 
Unbilled and other receivables(3,272)(1,358)
Reduction in the carrying amount of right of use assets4,812 4,724 
Prepaid expenses and other assets(6,837)(2,720)
Increase (decrease) in liabilities, net of acquisition:
Accounts payable2,597 (229)
Accrued payroll, taxes, and benefits499 2,010 
Deferred revenue(19,535)(10,190)
Lease liabilities920 (3,705)
Other accrued liabilities(126)1,611 
Net cash used in operating activities(94,741)(50,931)
Cash flows from investing activities:
Purchases of property and equipment(6,668)(6,210)
Purchases of equity investments(600)(3,700)
Distribution from equity investment11,825 375 
Proceeds from sale of equity investments— 15,735 
Acquisition, net of acquired cash(6,427)— 
Purchases of marketable securities(203,375)(340,509)
Proceeds from maturity of marketable securities283,711 339,588 
Net cash provided by investing activities78,466 5,279 
Cash flows from financing activities:
Issuances of common stock upon stock option exercises1,628 6,710 
Contribution by noncontrolling interest— 25 
Net cash provided by financing activities1,628 6,735 
Net decrease in cash and cash equivalents and restricted cash(14,647)(38,917)
Cash and cash equivalents and restricted cash, beginning of period123,267 202,796 
Cash and cash equivalents and restricted cash, end of period$108,620 $163,879 
Supplemental disclosure of cash flow and noncash information
Cash paid for income taxes$462 $236 
Supplemental disclosure of non-cash investing and financing activities
Purchases of property and equipment in accounts payable198 59 
Purchases of property and equipment in accrued liabilities109 — 
Acquisition of right to use assets, contingency resolution1,513 — 
Acquisition of right of use assets14,767 71,054 
Acquisition of lease liabilities14,767 71,054