1540 Broadway24th FloorNew YorkNYFALSE000149097800014909782023-05-042023-05-04

Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): May 4, 2023
Schrodinger, Inc.
(Exact name of Registrant as Specified in Its Charter)
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
(Commission File Number)
1540 Broadway, 24th Floor
New York, NY
(Address of principal executive offices)(Zip Code)
Registrant’s telephone number, including area code: (212) 295-5800
Not Applicable
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
oWritten communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
oSoliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
oPre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
oPre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading
Name of each exchange on which registered
Common stock, par value $0.01 per shareSDGRThe Nasdaq Stock Market LLC
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company o
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o

Item 2.02    Results of Operations and Financial Condition.
On May 4, 2023, Schrödinger, Inc. (the “Company”) issued a press release announcing its financial results for the first quarter ended March 31, 2023. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.
The information in this Form 8-K, including Exhibit 99.1 attached hereto, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing made by the Company under the Securities Act of 1933, as amended, or the Exchange Act, regardless of any general incorporation language in such filings, unless expressly incorporated by specific reference in such filing.
Item 9.01    Financial Statements and Exhibits.
104Cover Page Interactive Data File (embedded within the Inline XBRL document)

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
Schrödinger, Inc.
Date: May 4, 2023
By:/s/ Geoffrey Porges
 Geoffrey Porges, MBBS
Executive Vice President and Chief Financial Officer

Exhibit 99.1
Schrödinger Reports Strong First Quarter 2023 Financial Results

Delivered First Quarter Total Revenue of $64.8 Million, Driven by Strong Drug Discovery Revenue of $32.6 Million

Reports First Subjects Enrolled in Both Ongoing Phase 1 Study of MALT1 Inhibitor SGR-1505 and Newly Initiated Phase 1 Study in Healthy Subjects

Cash Position Significantly Strengthened by $147.3 Million Distribution from Sale of Nimbus’s TYK2 Inhibitor to Takeda

New York, May 4, 2023 – Schrödinger, Inc. (Nasdaq: SDGR), whose physics-based computational platform is transforming the way therapeutics and materials are discovered, today announced financial results for the first quarter ended March 31, 2023.

“We are very pleased with our achievements during the first quarter, which included strong contributions from our software business and our drug discovery collaborations,” stated Ramy Farid, Ph.D., chief executive officer of Schrödinger. “We are making excellent progress across our pipeline of proprietary and collaborative programs. We advanced the first program in our collaboration with BMS to development candidate status, and today reported that we have begun enrollment and dosing in both our ongoing Phase 1 study of SGR-1505 in patients with advanced B cell malignancies and our newly-initiated Phase 1 study in healthy volunteers. The transition to being a clinical-stage company represents a significant milestone for Schrödinger and an important step toward delivering our medicines to patients.”

“We delivered a very strong quarter, with software and drug discovery making equal contributions to our revenue result, reflecting our balanced business model. We also made substantial progress in both collaborative and proprietary programs and added capital to our balance sheet, and our partners achieved significant corporate and development milestones further validating our platform,” stated Geoff Porges, MBBS, chief financial officer of Schrödinger. “With our highly differentiated technology, our growing pipeline and our strong cash position, we are well positioned to achieve our goals for 2023 and beyond.”

First Quarter 2023 GAAP Financial Results
Total revenue for the first quarter increased 33% to $64.8 million, compared to $48.7 million in the first quarter of 2022.
Software revenue for the first quarter was $32.2 million, compared to $33.1 million in the first quarter of 2022. Software revenue in the first quarter of 2023 included a small number of multi-year agreements that did not fully offset revenue from multi-year agreements in the first quarter of 2022.
Drug discovery revenue was $32.6 million for the first quarter and included a $25 million milestone from BMS, compared to $15.6 million in the first quarter of 2022.
Software gross margin increased to 78% for the first quarter, compared to 77% in the first quarter of 2022.
Operating expenses were $76.2 million for the first quarter, compared to $56.6 million for the first quarter of 2022. The increase was driven by additional headcount to support the company’s progressing internal pipeline and its software business, CRO expenses, and royalties.
Other income for the first quarter was $186.0 million, primarily associated with changes in fair value of equity investments, interest income, and a $147.3 million gain relating to the cash distributions from Nimbus in connection with the sale of Nimbus’s TYK2 inhibitor to Takeda. Other expense for the first quarter of 2022 was $5.8 million driven primarily by changes in the fair value of the company’s equity investments.
Net income for the first quarter was $129.1 million, compared to net loss of $34.4 million in the first quarter of 2022.
During the first quarter, Schrödinger reported a non-cash tax expense of $26.4 million associated with the cash distribution from Nimbus.
At March 31, 2023, Schrödinger had cash, cash equivalents, restricted cash and marketable securities of approximately $532 million, compared to approximately $456 million at December 31, 2022.

Three Months Ended
March 31,
20232022% Change
(in millions)
Total revenue$64.8 $48.7 33%
Software revenue$32.2 $33.1 -3%
Drug discovery revenue$32.6 $15.6 109%
Software gross margin78 %77 %
Operating expenses$76.2 $56.6 35%
Other income (expense)$186.0 $(5.8)N/M
Net income (loss)$129.1 $(34.4)N/M

For the three months ended March 31, 2023, Schrödinger reported a non-GAAP net loss of $27.5 million compared to a non-GAAP net loss of $28.3 million for the three months ended March 31, 2022. See “Non-GAAP Information” below and the table at the end of this press release for a reconciliation of non-GAAP net income (loss) to GAAP net income (loss).

2023 Financial Outlook
As of May 4, 2023, Schrödinger maintained its financial guidance for the fiscal year ending December 31, 2023:
Software revenue growth is expected to be in the range of 13 to 17 percent
Drug discovery revenue is expected to range from $70 million to $90 million
Software gross margin is expected to be similar to software gross margin for the full year 2022
Operating expense growth in 2023 is expected to be significantly lower than operating expense growth in 2022 and to be similar to revenue growth in 2023
Cash used for operating activities in 2023 is expected to be below cash used for operating activities in 2022

For the second quarter of 2023, software revenue is expected to range from $27 million to $31 million.
Recent Highlights
In April, Schrödinger received a $36.0 million distribution, which is the second cash distribution from Nimbus Therapeutics in connection with Takeda’s acquisition of Nimbus Lakshmi, Inc., a wholly-owned subsidiary of Nimbus, and its tyrosine kinase 2 (TYK2) inhibitor NDI-034858. Schrödinger received the first distribution of $111.3 million in February 2023 for a total distribution of approximately $147.3 million, all of which was recognized as other income in the company’s first quarter 2023 financial results. NDI-034858 is being evaluated for the treatment of multiple autoimmune diseases following positive Phase 2b results in psoriasis.

In April, Schrödinger published its inaugural corporate sustainability report. The report highlights the company's vision and approach to corporate sustainability, summarizes the company’s 2022 achievements and discloses key data about its corporate sustainability efforts in alignment with GRI and SASB reporting standards.

Schrödinger continues to advance its MALT1 inhibitor, SGR-1505, in Phase 1 clinical development. A dose-escalation study designed to evaluate the safety, pharmacokinetics, pharmacodynamics, and early signals of clinical activity of SGR-1505 as a monotherapy is ongoing in patients with relapsed or refractory B-cell malignancies. Today Schrödinger announced that it has also initiated a Phase 1 study in healthy subjects to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SGR-1505.

Schrödinger is continuing to progress its CDC7 inhibitor, SGR-2921, through IND-enabling studies to support a planned IND submission in the first half of 2023. SGR-2921 has exhibited strong anti-tumor activity as a monotherapy and in combination with standard of care agents in multiple preclinical tumor models.

Schrödinger continues to advance its Wee1 inhibitor, SGR-3515, through IND-enabling studies to support a potential IND submission in 2024.

Schrödinger continues to advance its multi-target collaboration with BMS and today announced that it received a $25 million milestone payment associated with the advancement of the SOS1/KRAS program to development candidate status. This payment was recognized in drug discovery revenue in the first quarter of 2023.

Schrödinger’s collaborator, Morphic Therapeutic, made significant progress advancing MORF-057, an oral α4β7 integrin inhibitor, reporting positive topline results of the EMERALD-1 Phase 2a study in adults with moderate to severe ulcerative colitis (UC). MORF-057 achieved the primary endpoint and demonstrated consistent clinical improvement across other key measures with a favorable tolerability profile.

The company continues to progress a pipeline of early-stage wholly-owned programs with potential across a broad range of therapeutic areas. Schrödinger is planning to review its drug discovery programs during its Pipeline Day, a virtual and in-person event that will take place on September 28, 2023.

Schrödinger scientists published research showing how the company’s computational methods can be used to refine AlphaFold2 structures for hit discovery. While the publication of the open source AlphaFold protein structure database covers the complete human proteome and represents a significant scientific advance, computational methods are required to adequately refine the AlphaFold structures to improve their utility for drug discovery.

Schrödinger scientists published a study describing how FEP+ can be used with homology models for protein thermostability predictions, which can extend Schrödinger’s platform and the use of FEP+ thermostability prediction to targets for which an experimental structure is unavailable. Protein engineering for thermostability has a range of applications, including in the design of antibodies and in chemical industries where protein stability requires optimization to enable enzymes to withstand specific chemical conditions or to extend the shelf-life of protein products.

Webcast and Conference Call Information
Schrödinger will host a conference call to discuss its first quarter 2023 financial results on Thursday, May 4, 2023, at 4:30 p.m. ET. The live webcast can be accessed under "News & Events" in the investors section of Schrödinger’s website, To access the call by phone, please dial 1-888-396-8049 (domestic) or 1-416-764-8646 (international) and refer to conference ID 21402709. The archived webcast will be available on Schrödinger’s website for approximately 90 days following the event.

Non-GAAP Information
Included in this press release is certain financial information that has not been prepared in accordance with generally accepted accounting principles in the United States (GAAP). The company presents non-GAAP net income (loss) and non-GAAP net income (loss) per share, which exclude gains and losses on equity investments, changes in fair value, and non-cash income tax benefits and expenses relating to the company’s gains and losses on equity investments. Adjusting net income to exclude the impact of these items results in a financial presentation for the company without the impact of our equity investments. Management believes non-GAAP net income (loss) and non-GAAP net income (loss) per share are useful measures for investors, taken in conjunction with the company’s GAAP financial statements because they provide greater period-over-period comparability with respect to the company’s operating performance, by excluding non-cash mark-to-market and other valuation adjustments for our equity investments, non-recurring cash distributions from our equity investments and the tax impact of these distributions that are not reflective of the ongoing operating performance of the business. However, the non-GAAP measures should be considered only in addition to, not

as a substitute for or as superior to, net income (loss) and net income (loss) per share or other financial measures prepared in accordance with GAAP.

Other companies in our industry may calculate non-GAAP net income (loss) and non-GAAP net income (loss) per share, differently than we do, limiting their usefulness as comparative measures. For a reconciliation of non-GAAP net income (loss) and non-GAAP net income (loss) per share to GAAP net income (loss) and GAAP net income (loss) per share, respectively, please refer to the tables at the end of this press release.

About Schrödinger
Schrödinger is transforming the way therapeutics and materials are discovered. Schrödinger has pioneered a physics-based computational platform that enables discovery of high-quality, novel molecules for drug development and materials applications more rapidly and at lower cost compared to traditional methods. The software platform is licensed by biopharmaceutical and industrial companies, academic institutions, and government laboratories around the world. Schrödinger’s multidisciplinary drug discovery team also leverages the software platform to advance a portfolio of collaborative and proprietary programs to address unmet medical needs.

Founded in 1990, Schrödinger has approximately 800 employees and is engaged with customers and collaborators in more than 70 countries. To learn more, visit, follow us on LinkedIn and Instagram, or visit our blog,

Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including, but not limited to those statements regarding Schrödinger’s expectations about the speed and capacity of its computational platform, its financial outlook for the fiscal year ending December 31, 2023 and second quarter ending June 30, 2023, its plans to continue to invest in research and its strategic plans to accelerate the growth of its software licensing business and advance its collaborative and proprietary drug discovery programs, the long-term potential of its business, its ability to improve and advance the science underlying its platform, the initiation, timing, progress, and results of its proprietary drug discovery programs and product candidates and the drug discovery programs and product candidates of its collaborators, the clinical potential and favorable properties of its CDC7, MALT1, and Wee1 inhibitors, including SGR-1505, SGR-2921, and SGR-3515, the clinical potential and favorable properties of its collaborators’ product candidates, as well as expectations related to the use of its cash, cash equivalents and marketable securities. Statements including words such as “aim,” “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and statements in the future tense are forward-looking statements. These forward-looking statements reflect Schrödinger’s current views about its plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the company and on assumptions the company has made. Actual results may differ materially from those described in these forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and important factors that are beyond Schrödinger’s control, including the demand for its software platform, its ability to further develop its computational platform, its reliance upon third-party providers of cloud-based infrastructure to host its software solutions, factors adversely affecting the life sciences industry, fluctuations in the value of the U.S. dollar and foreign currencies, its reliance upon its third-party drug discovery collaborators, the uncertainties inherent in drug development and commercialization, such as the conduct of research activities and the timing of and its ability to initiate and complete preclinical studies and clinical trials, whether results from preclinical studies will be predictive of the results of later preclinical studies and clinical trials, uncertainties associated with the regulatory review of IND submissions, clinical trials and applications for marketing approvals, the ability to retain and hire key personnel and the direct and indirect impacts of the ongoing COVID-19 pandemic on its business and other risks detailed under the caption “Risk Factors” and elsewhere in the company’s Securities and Exchange Commission filings and reports, including its Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2023, filed with the Securities and Exchange Commission on May 4, 2023, as well as future filings and reports by the company. Any forward-looking statements contained in this press release speak only as of the date hereof. Except as required by law, Schrödinger undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events, changes in expectations or otherwise.

Jaren Irene Madden (Investors)
Schrödinger, Inc.

Allie Nicodemo (Media)
Schrödinger, Inc.

Condensed Consolidated Statements of Operations (Unaudited)
(in thousands, except for share and per share amounts)
Three months ended March 31,
Software products and services$32,213 $33,081 
Drug discovery32,569 15,582 
Total revenues64,782 48,663 
Cost of revenues:
Software products and services7,115 7,511 
Drug discovery11,974 13,169 
Total cost of revenues19,089 20,680 
Gross profit45,693 27,983 
Operating expenses:
Research and development40,741 27,822 
Sales and marketing9,145 6,671 
General and administrative26,308 22,133 
Total operating expenses76,194 56,626 
Loss from operations(30,501)(28,643)
Other income (expense):
Gain on equity investments147,322 — 
Change in fair value35,737 (6,164)
Other income2,937 339 
Total other income (expense)185,996 (5,825)
Income (loss) before income taxes155,495 (34,468)
Income tax expense (benefit)26,359 (28)
Net income (loss) 129,136 (34,440)
Net income (loss) per share of common and limited common stockholders, basic:$1.81 $(0.48)
Weighted average shares used to compute net income (loss) per share of common and limited common stockholders, basic:71,467,09771,050,432
Net income (loss) per share of common and limited common stockholders, diluted:$1.75 $(0.48)
Weighted average shares used to compute net income (loss) per share of common and limited common stockholders, diluted:73,818,61171,050,432

Condensed Consolidated Balance Sheets (Unaudited)
(in thousands, except for share and per share amounts)
AssetsMarch 31, 2023December 31, 2022
Current assets:
Cash and cash equivalents$233,206 $90,474 
Restricted cash4,486 5,243 
Marketable securities294,482 360,613 
Accounts receivable, net of allowance for doubtful accounts of $125 and $125
46,691 55,953 
Unbilled and other receivables, net for allowance for unbilled receivables of $100 and $100
13,473 13,137 
Prepaid expenses11,396 8,569 
Total current assets603,734 533,989 
Property and equipment, net16,493 14,244 
Equity investments101,539 25,683 
Goodwill4,791 4,791 
Intangible assets, net— 587 
Right of use assets105,982 105,982 
Other assets6,234 3,311 
Total assets$838,773 $688,587 
Liabilities and Stockholders' Equity:
Current liabilities:
Accounts payable$11,987 $9,470 
Income taxes payable26,318 355 
Accrued payroll, taxes, and benefits13,152 24,882 
Deferred revenue51,578 57,931 
Lease liabilities11,810 11,006 
Other accrued liabilities8,562 5,166 
Total current liabilities123,407 108,810 
Deferred revenue, long-term20,348 25,598 
Lease liabilities, long-term104,058 105,485 
Other liabilities, long-term700 800 
Total liabilities248,513 240,693 
Stockholders' equity:
Preferred stock, $$0.01 par value. Authorized 10,000,000 shares; zero shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively
— — 
Common stock, $$0.01 par value. Authorized 500,000,000 shares; 62,362,015 and 62,163,739 shares issued and outstanding at March 31, 2023 and December 31, 2022 , respectively
623 622 
Limited common stock, $$0.01 par value. Authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively
92 92 
Additional paid-in capital840,446 828,700 
Accumulated deficit(250,002)(379,138)
Accumulated other comprehensive loss(899)(2,382)
Total stockholders' equity of Schrödinger stockholders590,260 447,894 
Total liabilities and stockholders' equity$838,773 $688,587 

Condensed Consolidated Statements of Cash Flows (Unaudited)
(in thousands)
Three Months Ended March 31,
Cash flows from operating activities:
Net income (loss) $129,136 $(34,440)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Gain on equity investments(147,322)— 
Fair value adjustments(35,737)6,164 
Depreciation and amortization1,760 969 
Stock-based compensation10,880 9,134 
Noncash investment (accretion) amortization(964)1,504 
Gain on disposal of property and equipment— (4)
Decrease (increase) in assets, net of acquisition:
Accounts receivable, net9,262 2,935 
Unbilled and other receivables(336)(7,390)
Reduction in the carrying amount of right of use assets— 1,221 
Prepaid expenses and other assets(5,750)(7,725)
Increase (decrease) in liabilities, net of acquisition:
Accounts payable2,468 1,328 
Income taxes payable25,963 43 
Accrued payroll, taxes, and benefits(11,730)(7,454)
Deferred revenue(11,603)(7,079)
Lease liabilities(623)489 
Other accrued liabilities3,502 594 
Net cash used in operating activities(31,094)(39,711)
Cash flows from investing activities:
Purchases of property and equipment(3,580)(1,696)
Purchases of equity investments(4,125)— 
Distribution from equity investment111,329 — 
Acquisition, net of acquired cash— (6,427)
Purchases of marketable securities(58,823)(55,068)
Proceeds from maturity of marketable securities127,401 99,495 
Net cash provided by investing activities172,202 36,304 
Cash flows from financing activities:
Issuances of common stock upon stock option exercises867 908 
Contribution by noncontrolling interest— — 
Net cash provided by financing activities867 908 
Net increase (decrease) in cash and cash equivalents and restricted cash141,975 (2,499)
Cash and cash equivalents and restricted cash, beginning of period95,717 123,267 
Cash and cash equivalents and restricted cash, end of period$237,692 $120,768 
Supplemental disclosure of cash flow and noncash information
Cash paid for income taxes$86 $37 
Supplemental disclosure of non-cash investing and financing activities
Purchases of property and equipment in accounts payable218 317 
Purchases of property and equipment in accrued liabilities86 343 
Acquisition of right to use assets, contingency resolution1,820 1,513 
Acquisition of right of use assets— 1,146 
Acquisition of lease liabilities— 1,146 

Reconciliation of GAAP to Non-GAAP Financial Measures (Unaudited)

Three Months Ended
March 31,
(in thousands, except per share data)
Net income (loss) (GAAP)$129,136 $(34,440)
                     Income tax expense (benefit)26,359 — 
                     Gain on equity investments(147,322)— 
                     Change in fair value (35,737)6,164 
Non-GAAP net loss$(27,564)$(28,276)
Non-GAAP net income (loss) per share of common and limited common stockholders, basic and diluted$(0.38)$(0.40)